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Comprehensive Physiology (the online version of the Handbook of Physiology) is the most wide-ranging and authoritative collection of review content ever assembled in the physiological sciences. Comprehensive Physiology includes the landmark series Handbook of Physiology, available for the first time in an online format. This seminal series will be continually updated and expanded to capture the current science of physiology for a twenty-first-century readership. {RG 12/16/13}