Blaisdell Medical Library
by Amy Studer – January 5, 2020
This guide is designed to support drug discovery, development, and commercialization efforts of researchers, students, faculty, and staff at UC Davis.
As the official provider of FDA label information (package inserts), DailyMed provides trustworthy information about marketed drugs in the United States. The over 8,000 drug records link to related government websites, such as: FDA Recalls, Market Withdrawals & Safety Alerts; ClinicalTrials.gov; and LactMed.
This Web site provides a standard, comprehensive, up-to-date, look-up and download resource of medication content and labeling found in medication package inserts. The drug labeling information on this Web site is the most recent submitted to the Food and Drug Administration (FDA) and currently in use; it may include, for example, strengthened warnings undergoing FDA review or minor editorial changes. Access to archived labels is provided.
US Food and Drug Administration (FDA)
The FDA website includes information about human drugs, vaccines, blood products and biologics, medical devices, plus veterinary and animal drugs. Information is provided about the regulatory process. Home page links to specific content for health consumers, providers, researchers, and industry.
NLM Drug Information Portal
Provides cross-database search by drug name or category for multiple NLM and US Government resources: Drugs@FDA, DailyMed, PubChem, TOXNET, ClinicalTrials.gov. This enables navigation to drug and dietary supplement labels, drug structure and physical property information, and FDA approval documents.
Databases available via the MicroMedexHealth link are: P&T Quik Reports, Physicians Desk Reference (PDR), Martindale International drug information – including investigational and herbal drugs, POISINDEX, and DRUGDEX (Consults and Evaluations), MSDS from USP, POISINDEX, REPRORISK, DESEASEDEX (General and Emergency), Alternative Medicine, TOMES, RED BOOK, and NeoFax .
These databases provide information on drugs including: administration, adverse effects, clinical applications, contraindications, dosage, indications, interactions, over-dosage, pharmacology, precautions, product/substance identification, toxicity, references, synonyms, and uses.For drug pricing information, use RED BOOK. From the Micromedex homepage –> select “Other tools” in the top menu.
Facts & Comparisons eAnswers
This is an important drug databases for pharmacists, physicians and other clinicians. Includes dosing tools, clinical calculators, and information about drugs, orphan drugs, and off-label use.
(USP-NF) United States Pharmacopeia National Formulary
USP–NF is a combination of two compendia, the United States Pharmacopeia (USP) and the National Formulary (NF). Monographs for drug substances, dosage forms, and compounded preparations are featured in the USP. Monographs for dietary supplements and ingredients appear in a separate section of the USP. Excipient monographs are in the NF. [See UC Davis Library catalog public note for login information]
For additional resources, see Drug Development tab.
Requires registration–see SciFinder Tutorials. This is a great place to start looking for information about a drug product’s active ingredients, formulation, and excipients because it covers the chemical literature and patent literature. SciFinder is the comprehensive database for scholarly research in the field of chemistry. It contains over 29 million citations from over 10,000 journals, covering all aspects of chemistry, including chemical aspects of: biology and life sciences, engineering and materials science, food science, geology, medicine, physics, and polymer science. SciFinder also allows searching of chemical substances, chemical reactions, and includes some property data and spectra. Cited Reference Searching: 1996 – present. Coverage: 1907 – present (with selected pre-1907 material).
PubChem: Open Chemistry Database
PubChem provides information on the biological activities of small molecules in three main databases: PcBioassay, PcCompound, adn PcSubstance. PubChem is integrated with Entrez, NCBI’s primary search engine, and also provides compound neighboring, sub/superstructure, structure, targets, BioActivity data, and patents.
A free database of 350,000 chemical compounds. Records consist of name, synonyms, CAS number, molecular formula, similar structures and 3D viewer. Part of the TOXNET suite of databases.
Searches literature from the biological sciences. More than 23 million records in all life science areas, including agriculture, biochemistry, biomedicine, biotechnology, ecology, environmental sciences, genetics, microbiology, plant biology, veterinary medicine & pharmacology, and zoology. Indexes over 6000 journals, serials, books and book chapters, conference proceedings and patents. Coverage: 1926 to present.
US government-provided databases on toxicology, hazardous chemicals, environmental health, and toxic releases. TOXNET has been retired as of December 16, 2019; however, many of the former TOXNET databases have been incorporated into other NLM resources.
One-Time Registration (on-campus):
1. Go to the UC SciFinder website, under “New User?” select Davis (UCD).
2. Review the instructions for creating a username/password, click the registration link at end of the page. You must register with your “ucdavis.edu” email account.
3. When you receive a confirmation email, click the link in the message to complete the registration. Check your spam folder if you do not see the confirmation email in your inbox.
4. Once you have an account, logon to SciFinder.
One-Time Registration (off-campus):
First, log in thru the VPN, then complete steps 1-3 above.
SciFinder Training Materials
Short video tutorials about searching for structures, literature, and reactions.
For additional resources, see Drug Discovery tab.
Drugs@FDA allows you to search for official information about FDA approved brand name and generic drugs and therapeutic biological products. The main uses of Drugs@FDA are:
FDA: Drug Approvals & Databases
Serves as a portal for FDA drug approval and reporting systems, including:
Embase is a biomedical and pharmacological database containing bibliographic records with citations, abstracts and indexing derived from biomedical articles in peer reviewed journals, and is especially strong in its coverage of medical device, drug and pharmaceutical research and conference abstracts. Excellent source of articles related to post-market research. MEDLINE results are included along with significant unique content with international coverage. Embase contains over 22 million records spanning 1974-present. Search tools include a specialized drug search interface and a pharmacovigilence wizard (PV Wizard).
ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The FDA requires registration of clinical trials and reporting of basic results and adverse event data for drug and device trials.
PubMed is the National Library of Medicine’s search service that provides access to over 27 million biomedical literature citations from MEDLINE, life science journals, and online books. Provides a good entry point for navigation to the NCBI bioinformatics databases containing genetic and genomic information, tools and data. Coverage: 1946 to present.
Scopus indexes, selectively abstracts and provides citation analysis for approximately 22,000 peer-reviewed journals from more than 5,000 international publishers, as well as published sets of conference proceedings, trade publications, books, patents (from the USPTO, European Patent Office, Japan Patent office, World Intellectual Property Organization and the UK Intellectual Property Office) and millions of selected web pages. Coverage extends across disciplines in the life and health sciences, the physical sciences, the social sciences and the arts and humanities. Scopus features tools to track, analyze and visualize research.
Web of Science
Provides article and citation searching in the sciences, social sciences, arts and humanities via: Science Citation Index Expanded, Social Sciences Citation Index, and Arts and Humanities Citation Index. Indexed materials include research data, books, journals, proceedings, publications and patents. Coverage: 1900 – present.
In addition to these resources, don’t forget to take a look at drug company websites.
Factiva provides access to global news and business information, including local newspapers, same-day newswires, company reports, and media programs. Provides company information including market data and competitors. Includes full-text of the Wall Street Journal. Coverage in more than 20 languages.
*To increase relevance, limit results to the pharmaceutical industry.
Business Source Complete
Provides full text for more than 7,400 scholarly business journals and other sources, including peer-reviewed business publications. Coverage includes all subject areas related to business including management, economics, finance, accounting, international business, marketing and more. Coverage: varies by title with some going as far back as 1886.
Nexis Uni [formerly Lexis-Nexis Academic]
One of the largest web-based full-text databases for current news, business and legal information, supporting a broad range of interdisciplinary research, Nexis Uni (known until December 2017 as LexisNexis Academic) provides full-text access to nearly 6,000 individual titles. Includes a wide range of U.S. and foreign newspapers, plus transcripts of television and radio news programs. Business resources include business articles, accounting literature, company financial information. Legal resources include state and federal laws and regulations, a full range of case law, and law review articles.
Patents are a good source for information on drug chemistry as well as manufacturing processes.
A Few Quick Options:
SEARCH Find Free Patents Online (FPO) — find pdfs of selected patents
SEARCH the USPTO Patent Database — for granted patents and patent applications
From the USPTO:
To search the entire collection, go to Library Catalog tab in the Library Search tool.
The eBooks listed on this page are just a few of the holdings at UC Davis University Library. To search the entire collection, use Library Search or Melvyl.
To get to these eBooks, you must access from a UC Davis networked computer or be logged onto the Library VPN (Pulse Secure).
Image credit: Kate Marusina, PhD, MBA, Director of Clinical Trials, UC Davis Clinical and Translational Sciences Center. Used with permission.
During this course, you will:
Training in Neurotherapeutics Discovery and Development
In addition to providing content for a course offered by Michael Rogawski, MD and collaborators, includes other resources for learning about the process of drug discovery and development.
Thanks to the following librarians: Penny Coppernoll-Blach at the Biomedical LIbrary, UC San Diego; Edith Starbuck and Kristen Burgess at the University of Cininnati Libraries; and, Adam Seigel, Cory Craig, Bruce Abbott, and Axel Borg from the UC Davis Library.