Science of Synthesis provides an authoritative review of synthetic methods from the early 1800s to the present, for the field of organic and organometallic chemistry. Science of Synthesis is full-text, structure, and reaction searchable. The database also provides links to the primary literature and to related information in the Houben-Weyl electronic archive. (All 4 editions, and the supplemental “E-series” volumes, of the Houben-Weyl Methods of Molecular Transformations are included in Science of Synthesis.)

REAXYS is the web-based replacement for the CrossFire platform. It provides access to chemical property, structure, and reaction data from the Beilstein (organic chemistry) and Gmelin (inorganic and organometallic chemistry) databases. The Beilstein database contains information on over 8 million compounds and more than 5 million chemical reactions. It provides comprehensive coverage of reactions, structures, and properties in organic chemistry; as well as references to the literature. For each compound, up to 350 chemical and physical data fields of critically evaluated data are available. The Gmelin database contains information on over 1.4 million compounds, including: coordination compounds, alloys, solid solutions, glasses and ceramics, polymers, and minerals. It provides comprehensive coverage of structures and properties in inorganic and organometallic chemistry; references to the literature and information on reactions (over 900,000) are also included.